rti 111 что это

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

DISCLAIMER: PW’s dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Dichloropane (also known as RTI-111 or O-401) is a novel stimulant substance of the phenyltropane class. [1] Its effects include stimulation, thought acceleration, appetite suppression and euphoria. It is structurally related to cocaine and shares many of its effects, although it notably lacks its local anesthetic properties.

Dichloropane has been shown to have a slower onset and longer duration of action compared to cocaine in animal studies. [2] Anecdotal reports characterize it as having the basic stimulant qualities of cocaine but without as much euphoria, more protracted comedown, and less general enjoyability.

Dichloropane first appeared on the research chemical market around 2010. It is among to the first cocaine analog to be made available (in limited quantities) on the online research chemical market.

Very little is known about the pharmacology, metabolism, and toxicity of dichloropane. It is highly advised to use harm reduction practices if using this substance.

Contents

Chemistry

This chemistry section is incomplete.

Dichloropane is structurally similar to cocaine, atropine and hyoscine, as it contains a tropane ring. The tropane ring of RTI-11 is substituted with a carbomethoxy group, also found in cocaine. RTI-111 differs from cocaine by its other addition, a dichlorinated phenyl ring. The phenyl ring of RTI-111 is substituted at R₃ and R₄ with chlorine groups. The phenyl ring of RTI-111 is attached directly to its tropane ring while in cocaine a carboxylate group bridges the two rings.

Pharmacology

The most extensively studied effect of dichloropane on the central nervous system is the blockade of the serotonin, dopamine, and norepinephrine transporter. [5] This substance acts as a triple reuptake inhibitor and prevents monoamine neurotransmitters from being recycled, causing excessive amounts to build up in the synapse, or junction between neurons. The result is an enhanced and prolonged post-synaptic effect of monoaminergic signaling at receptors on the receiving neuron. It is this sudden flood of neurotransmitters in the synapses of various brain regions that is thought to cause dichloropane’s effects. [6]

Compared to cocaine, dichloropane has a higher relative affinity for both the serotonin and norepinephrine transporters over the dopamine transporter, which is in part suspected to be responsible for the differences in its subjective effects.

Subjective effects

The general head space of dichloropane is described by many as one of moderate to extreme mental stimulation, increased focus, sociability and euphoria.

Unlike cocaine, dichloropane is reported to produce a minimal rush component combined with a substantially longer come-up, protracted comedown and overall duration. This may render it less compulsive than cocaine for some users, but with a proportionally harder offset.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

Cognitive effects

After effects

Experience reports

Anecdotal reports which describe the effects of this compound within our experience index include:

Toxicity and harm potential

The toxicity and long-term health effects of recreational dichloropane use has not been studied in any scientific context and the exact toxic dosage is unknown. This is because dichloropane has very little history of human usage. In terms of neurotoxicity (as defined by the damage or death of cells in the brain in response to over-excitation or reactive oxidation caused by drugs), it is reasonable to assume that like other stimulants which work principally through reuptake inhibition (e.g. cocaine), dichloropane should not exhibit these effects unlike certain other substances such as methamphetamine, which have suspected mechanisms of direct neurotoxicity. The extended use or abuse of dichloropane, however, is likely to cause both short and down-term down regulation of the receptors of the major neurotransmitter (monoamine) systems it interacts with. However, this still remains a subject of active inquiry.

Due to its structural similarity to cocaine, it is worth noting that the most potentially harmful physical effects of dichloropane could not be neurological but cardiovascular. For example, severe cardiac adverse events, particularly sudden cardiac death, become a serious risk at high doses for cocaine due to cocaine’s blocking effect on cardiac sodium channels, and it is possible that dichloropane may share this risk despite not having topical anesthetic activity. [9] Moreover, long-term cocaine usage may result in Cocaine-Related Cardiomyopathy. [10] It is as of yet unknown whether dichloropane presents similar risks, but it is reasonable to assume that it might, and thus should be approached with additional caution.

It is suspected that regular dichloropane insufflation can have extremely adverse effects on one’s nostrils, nose and nasal cavities. These include a loss of the sense of smell, nosebleeds, difficulty swallowing, hoarseness, or a chronically runny nose.

Anecdotal evidence from people who have tried dichloropane within the community suggest that there do not seem to be any negative health effects attributed to simply trying this substance at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

As with other stimulants, the chronic use of dichloropane can be considered to have the potential to be moderately addictive with a high potential for abuse, though perhaps less so than that of cocaine, and is thus capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

Withdrawal symptoms

It is possible that after taking dichloropane on a regular or extended basis, some users will become addicted like they would to cocaine. When the drug is discontinued immediately, the user will experience what has come to be known as a «crash» along with a number of other withdrawal symptoms including paranoia, depression, anxiety, itching, mood swings, irritability, fatigue, insomnia, an intense craving for more of the drug, and, in some cases, nausea and vomiting. Some cocaine users also report having similar symptoms to schizophrenic patients and feel that their mind is scattered or incoherent. Some users also report a feeling of a crawling sensation on the skin also known as «coke bugs».

These symptoms can last for weeks or, in some cases, months. Even after most withdrawal symptoms dissipate most users feel the need to continue using the drug; this feeling can last for years and may peak during times of stress.

Psychosis

Due to its very brief history of human usage, little is known about dichloropane’s ability to induce psychosis, although it is reasonable to assume it presents similar risks to that of cocaine and other dopaminergic stimulants when abused, typically for extended durations, in high doses and or for prolonged periods of time.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous or even life-threatening when combined with certain other substances. The following lists some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Legal status

This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

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